MEXICO CITY, MEXICO - JUNE 30: Queen Letizia looks on during the encounter with the Iberoamerican Alliance for Rare Diseases at Presidente Hotel on June 30, 2015 in Mexico City, Mexico. The Spanish Monarchs are in their second state visit since the proclamation of Felipe VI as Spanish King last June 19th of 2014. (Photo by Manuel Velasquez/LatinContent via Getty Images)