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MADRID, SPAIN - MARCH 05: Queen Letizia of Spain attends the Rare Diseases World Day ceremony at Spanish Senate on March 5, 2015 in Madrid, Spain. (Photo by Pablo Cuadra/Getty Images)

MADRID, SPAIN - MARCH 05:  Queen Letizia of Spain attends the Rare Diseases World Day ceremony at Spanish Senate on March 5, 2015 in Madrid, Spain.  (Photo by Pablo Cuadra/Getty Images)