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MADRID, SPAIN - JULY 07: In this Handout images provided by the Spanish Royal Household, Queen Letizia of Spain speaks on a digital intervention at United Nations High Level Forum about the challenges of people living with rare diseases, on July 07, 2021 in Madrid, Spain. (Photo by Handout/Getty Images)

MADRID, SPAIN - JULY 07: In this Handout images provided by the Spanish Royal Household, Queen Letizia of Spain speaks on a digital intervention at United Nations High Level Forum about the challenges of people living with rare diseases, on July 07, 2021 in Madrid, Spain. (Photo by Handout/Getty Images)