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MADRID, SPAIN - MARCH 03: Queen Letizia of Spain attends the Rare Diseases World Day at CSIC headquarters on March 3, 2016 in Madrid, Spain. (Photo by Europa Press/Europa Press via Getty Images)

MADRID, SPAIN - MARCH 03:  Queen Letizia of Spain attends the Rare Diseases World Day at CSIC headquarters on March 3, 2016 in Madrid, Spain.  (Photo by Europa Press/Europa Press via Getty Images)