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MADRID, SPAIN - MARCH 03: Queen Letizia of Spain attends the Rare Diseases World Day Event at the CSIC on March 3, 2016 in Madrid, Spain. (Photo by Fotonoticias/WireImage)

MADRID, SPAIN - MARCH 03:  Queen Letizia of Spain attends the Rare Diseases World Day Event at the CSIC on March 3, 2016 in Madrid, Spain.  (Photo by Fotonoticias/WireImage)